解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:Pneumococcus is exposed to a variety of temperature and oxygen levels in the upper respiratory tract and as it invades the lung, tissues, and blood. We sought to determine the effect of environmental variability on growth in vitro and to assess variability between strains. We evaluated the effect of temperat...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1671-8
更新日期:2019-12-26 00:00:00
abstract:BACKGROUND:Wolbachia, one of the most abundant taxa of intracellular Alphaproteobacteria, is widespread among arthropods and filarial nematodes. The presence of these maternally inherited bacteria is associated with modifications of host fitness, including a variety of reproductive abnormalities, such as cytoplasmic in...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1652-y
更新日期:2019-12-24 00:00:00
abstract:BACKGROUND:Mass-rearing, domestication and gamma irradiation of tephritid fruit flies used in sterile insect technique (SIT) programmes can negatively impact fly quality and performance. Symbiotic bacteria supplied as probiotics to mass-reared fruit flies may help to overcome some of these issues. However, the effects ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1649-6
更新日期:2019-12-24 00:00:00
abstract:BACKGROUND:Listeria monocytogenes is the causative agent of listeriosis, a serious disease affecting both animals and humans. Here, multilocus sequence typing (MLST) was used to characterize the genetic diversity of Listeria monocytogenes strains isolated from the natural environment and animal clinical cases in Europe...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1676-3
更新日期:2019-12-18 00:00:00
abstract:BACKGROUND:The complete genome sequences of 44 Bacillus cereus group isolates collected from diverse sources in Japan were analyzed to determine their genetic backgrounds and diversity levels in Japan. Multilocus sequence typing (MLST) and core-genome single-nucleotide polymorphism (SNP) typing data from whole-genome s...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1678-1
更新日期:2019-12-16 00:00:00
abstract:BACKGROUND:Chlortetracycline (CTC) is one of the commercially important tetracyclines (TCs) family product and is mainly produced by Streptomyces. CTC is still in a great demand due to its broad-spectrum activity against pathogens. Engineering transcriptional control allows the cell to allocate its valuable resources t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1670-9
更新日期:2019-12-10 00:00:00
abstract:BACKGROUND:HSV-1 is a common pathogen that infects 50-90% of the human population worldwide. HSV-1 causes numerous infection-related diseases, some of which are severely life-threatening. There are antiviral medications with activity against HSV-1. However, with the emergence of drug-resistant mutant strains of HSV-1, ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1639-8
更新日期:2019-12-07 00:00:00
abstract:BACKGROUND:Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host, are now accepted as suitable alternatives to antibiotics in the control of animal infections and improving animal production. Lactic acid bacteria (LAB) with remarkable functional properties h...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1626-0
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Streptomyces lividans is an appealing host for the production of proteins of biotechnological interest due to its relaxed exogenous DNA restriction system and its ability to secrete proteins directly to the medium through the major Sec or the minor Tat routes. Often, protein secretion displays non-uniform ti...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1591-7
更新日期:2019-10-26 00:00:00
abstract:BACKGROUND:Ustilago esculenta, a typical dimorphic fungus could infect Zizania latifolia and induce host stem swollen to form an edible vegetable called Jiaobai in China. The strains differentiation especially in the mating ability and pathogenicity is closely related to different phenotypes of Jiaobai formed in the fi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1588-2
更新日期:2019-09-05 00:00:00
abstract:BACKGROUND:Comparative knowledge of microbiomes and resistomes across environmental interfaces between animal production systems and urban settings is lacking. In this study, we executed a comparative analysis of the microbiota and resistomes of metagenomes from cattle feces, catch basin water, manured agricultural soi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1548-x
更新日期:2019-08-27 00:00:00
abstract:BACKGROUND:Despite the importance of the B. cereus group as major foodborne pathogens that may cause diarrheal and/or emetic syndrome(s), no study in Tunisia has been conducted in order to characterize the pathogenic potential of the B. cereus group. The aim of this study was to assess the sanitary potential risks of 1...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1571-y
更新日期:2019-08-24 00:00:00
abstract:BACKGROUND:The low bacterial load in samples acquired from the lungs, have made studies on the airway microbiome vulnerable to contamination from bacterial DNA introduced during sampling and laboratory processing. We have examined the impact of laboratory contamination on samples collected from the lower airways by pro...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1560-1
更新日期:2019-08-14 00:00:00
abstract:BACKGROUND:The human gastrointestinal (GI) tract microbiota has been a subject of intense research throughout the 3rd Millennium. Now that a general picture about microbiota composition in health and disease is emerging, questions about factors determining development of microbiotas with specific community structures w...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1538-z
更新日期:2019-07-18 00:00:00
abstract:BACKGROUND:Recently, in India, there has been a shift from NDM to OXA48-like carbapenemases. OXA-181 and OXA-232 are the frequently produced variants of OXA48-like carbapenemases. OXA48-like carbapenemases are also known to be carried on transposons such as Tn1999, Tn1999.2 and it is also associated with IS1R carried o...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1513-8
更新日期:2019-06-24 00:00:00
abstract:BACKGROUND:A major obstacle to industrial-scale astaxanthin production by the yeast Phaffia rhodozyma is the strong inhibitory effect of high glucose concentration on astaxanthin synthesis. We investigated, for the first time, the mechanism of the regulatory effect of high glucose (> 100 g/L) at the metabolite and tran...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1507-6
更新日期:2019-06-15 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) is known as a leading cause of morbidity and mortality. Investigation of the MRSA's virulence and resistance mechanisms is a continuing concern toward controlling such burdens through using high throughput whole Genome Sequencing (WGS) and molecular diagnost...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1470-2
更新日期:2019-06-11 00:00:00
abstract:BACKGROUND:Macrolides and lincosamides are two leading types of antibiotics commonly used in therapies. The study examines the differences in resistance to these antibiotics and their molecular bases in S. epidermidis as well as in rarely isolated species of coagulase-negative staphylococci such as S. hominis, S. haemo...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1496-5
更新日期:2019-06-10 00:00:00
abstract:BACKGROUND:Although the most widely accepted mechanism of action for polymyxins is related to bacterial lysis via disruption, we hypothesized that this antimicrobial drug class could have other effects on Pseudomonas aeruginosa planktonic and sessile cells. Little is known regarding oxidative burst and zeta potential (...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1485-8
更新日期:2019-05-29 00:00:00
abstract:BACKGROUND:Methicillin-resistant Staphylococcus aureus (MRSA) biofilm producers represent an important etiological agent of many chronic human infections. Antibiotics and host immune responses are largely ineffective against bacteria within biofilms. Alternative actions and novel antimicrobials should be considered. In...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1484-9
更新日期:2019-05-28 00:00:00
abstract:BACKGROUND:Infection with Brucella melitensis (B. melitensis) is one of the most important causes of abortion in goats and sheep, and also causes severe systemic disease in exposed humans. In Ethiopia, based on seroepidemiological studies, brucellosis is known to be endemic. However, there is little information on the ...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1474-y
更新日期:2019-05-24 00:00:00
abstract:BACKGROUND:Hfq is a widely conserved bacterial RNA-binding protein which generally mediates the global regulatory activities involv ed in physiological process and virulence. The goal of this study was to characterize the biological function of hfq gene in Xanthomonas axonpodis pv. citri (Xac), the causal agent of citr...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1476-9
更新日期:2019-05-22 00:00:00
abstract:BACKGROUND:Several conventional methods, including fungal culture and periodic acid-Schiff (PAS) reagent staining, have been used to diagnose oral candidiasis. The aim of this study was to evaluate the efficacy of a novel method, fungal fluorescent staining, in relation to conventional protocols in the diagnosis of ora...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1467-x
更新日期:2019-05-14 00:00:00
abstract:BACKGROUND:Cathepsins are a group of endosomal proteases present in many cells including dendritic cells (DCs). The activity of cathepsins is regulated by their endogenous inhibitors - cystatins. Cathepsins are crucial to antigen processing during viral and bacterial infections, and as such are a prerequisite to antige...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1471-1
更新日期:2019-05-10 00:00:00
abstract:BACKGROUND:The use of chemical fungicides against fungal pathogens adversely affects soil and plant health thereby resulting in overall environmental hazards. Therefore, biological source for obtaining antifungal agents is considered as an environment-friendly alternative for controlling fungal pathogens. RESULTS:In t...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1440-8
更新日期:2019-04-02 00:00:00
abstract:BACKGROUND:The opportunistic pathogen, Pseudomonas aeruginosa is well known for its environmental and metabolic versatility, yet many of the functions of its gene-products remain to be fully elucidated. This study's objective was to illuminate the potential functions of under-described gene-products during the medicall...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1441-7
更新日期:2019-04-01 00:00:00
abstract:BACKGROUND:Porphyromonas gingivalis, a microorganism residing in the oral cavity within complex multispecies biofilms, is one of the keystone pathogens in the onset and progression of periodontitis. In this in vitro study, using DNA microarray, we investigate the differential gene expression of Porphyromonas gingivalis...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1423-9
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Extended-spectrum cephalosporin resistance (ESC-R) in Escherichia coli and Klebsiella pneumoniae is a healthcare threat; high gastrointestinal carriage rates are reported from South-east Asia. Colonisation prevalence data in Cambodia are lacking. The aim of this study was to determine gastrointestinal coloni...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1431-9
更新日期:2019-03-12 00:00:00
abstract:BACKGROUND:Edwardsiella ictaluri is a Gram-negative facultative intracellular anaerobe and the etiologic agent of enteric septicemia of channel catfish (ESC). To the catfish industry, ESC is a devastating disease due to production losses and treatment costs. Identification of virulence mechanisms of E. ictaluri is crit...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1429-3
更新日期:2019-03-08 00:00:00
abstract:BACKGROUND:This study provides biochemical and molecular genetic characteristics of P. multocida isolated from dead saigas in 1988, 2010-2015 on the territory of the Republic of Kazakhstan. RESULTS:Bacteriological samples taken from carcasses of saiga antelope during mortality events recorded in West Kazakhstan in bot...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1407-9
更新日期:2019-02-11 00:00:00
abstract:BACKGROUND:Single stranded ribonucleic acid (ssRNA) binds to toll-like receptor (TLR)7 leading to recruitment of immune cells and production of pro-inflammatory cytokines, which has been shown in mammals. In chickens, synthetic ssRNA analog, resiquimod, has been shown to elicit antiviral response against infectious bur...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-019-1398-6
更新日期:2019-02-08 00:00:00
abstract:BACKGROUND:Antimicrobial helper-compounds may reverse antimicrobial resistance. Sertraline, a antidepressant drug, has been suggested as a tetracycline helper-compound. Tetracycline is the preferred antimicrobial for treatment of enteric diseases in pigs. This study is the first to evaluate the potency of sertraline as...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1383-5
更新日期:2019-01-11 00:00:00
abstract:BACKGROUND:There is an urgent need to develop potent antimicrobials for the treatment of infections caused by antibiotic-resistant bacterial pathogens. Paenipeptin C' (C8-Pat) is a novel linear lipopeptide recently discovered by our group. The objectives of this study were to determine the time-kill kinetics of paenipe...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1381-7
更新日期:2019-01-08 00:00:00
abstract:BACKGROUND:We performed a 12-month cohort study of the stability and resilience of the intestinal microbiota of healthy children in daycare in Denmark in relation to diarrheal events and exposure to known risk factors for gastrointestinal health such as travelling and antibiotic use. In addition, we analyzed how gut mi...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1367-5
更新日期:2018-12-22 00:00:00
abstract:BACKGROUND:Lactobacillus plantarum, a versatile lactic acid-fermenting bacterium, isolated from the traditional pickles in Ningbo of China, was chosen for grass carp fermentation, which could also improve the flavor of grass carp. We here explored the central metabolic pathways of L. plantarum by using metabolomic appr...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1354-x
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Human granulocytic anaplasmosis (HGA) is a tick-borne disease caused by the etiologic agent Anaplasma phagocytophilum. HGA was designated a nationally notifiable disease in the United States in 1998. Currently there are no vaccines available against HGA. Conserved membrane proteins that are subdominant in An...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1346-x
更新日期:2018-12-18 00:00:00
abstract:BACKGROUND:Modifiable lifestyle factors (e.g. dietary intake and physical activity) are important contributors to weight gain during college. The purpose of this study was to evaluate whether associations exist between body mass index, physical activity, screen time, dietary consumption (fat, protein, carbohydrates, an...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1362-x
更新日期:2018-12-12 00:00:00
abstract:: ...
journal_title:BMC microbiology
pub_type:
doi:10.1186/s12866-018-1279-4
更新日期:2018-11-23 00:00:00
abstract:BACKGROUND:Tsetse flies (Diptera: Glossinidae) are solely responsible for the transmission of African trypanosomes, causative agents of sleeping sickness in humans and nagana in livestock. Due to the lack of efficient vaccines and the emergence of drug resistance, vector control approaches such as the sterile insect te...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1295-4
更新日期:2018-11-23 00:00:00
abstract:BACKGROUND:Lactic acid bacteria (LAB) are major inhabitants and part of the normal microflora of the gastrointestinal tract (GIT) of humans and animals. Despite substantial evidence supporting the beneficial properties of LAB, only a few studies have addressed the migration and colonization of probiotic bacteria in the...
journal_title:BMC microbiology
pub_type: 杂志文章
doi:10.1186/s12866-018-1315-4
更新日期:2018-10-30 00:00:00